• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of Actin associated cell skeletal protein in peripheral nerve regeneration-CLP36 interaction with palladin-

Research Project

Project/Area Number 20791028
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

HASEGAWA Tomohiko  Hamamatsu University School of Medicine, 整形外科, 助教 (50402368)

Co-Investigator(Renkei-kenkyūsha) OHNO Koji  浜松医科大学, 解剖学, 准教授 (90263277)
Research Collaborator FUNAHASHI Shinji  浜松医科大学 (10402364)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsCLP36 / Palladin / Yeast two hybrid / actin PDZ domain / LIM domain / palladin / 細胞骨格 / 神経再生 / PDZ domain
Research Abstract

CLP36, a member of the alpha-actinin-associated LIM protein (ALP)/enigma protein family, plays a role in neurite outgrowth in the peripheral nervous system. we had performed yeast two-hybrid screening, identified palladin as a CLP36-binding protein. A coimmunoprecipitation study showed that CLP36 and palladin formed a complex in the dorsal root ganglion (DRG). In addition, CLP36 and palladin were colocalized in the neurites and cell bodies of primary DRG neurons. Furthermore, sciatic nerve transection increased the expression of both CLP36 and palladin mRNAs in DRG neurons, with the increase in CLP36 mRNA being more prominent. This implies that CLP36 has a more specific role in nerve regeneration than palladin. Our results suggest that CLP36 may interact with palladin to influence neurite outgrowth

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (3 results)

All 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Remarks (1 results)

  • [Journal Article] CLP36 interacts with palladin in dorsal root ganglion neurons.2010

    • Author(s)
      Hasegawa T, Ohno K, Funahashi S, Miyazaki K, Nagano A, Sato K
    • Journal Title

      Neurosci Lett 476(2)

      Pages: 53-57

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] CLP36 interacts with paladin in dorsal root ganglion neurons2010

    • Author(s)
      Tomohiko Hasegawa
    • Journal Title

      Neuroscience Letters

      Volume: 476 Pages: 53-57

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi