Therapeutic development of intervertebral disc degeneration targeting proteinase-activated receptor
Project/Area Number |
20791030
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Orthopaedic surgery
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Research Institution | Mie University |
Principal Investigator |
AKEDA Koji Mie University, 医学部・附属病院, 助教 (20422826)
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Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 椎間板 / サイトカイン / 蛋白分解酵素 / 細胞外基質 / 椎間板変性 |
Research Abstract |
The results of this study show that intervertebral disc (IVD) cells express PAR-2. The expression of PAR-2 is regulated by IL-1β stimulation. PAR-2 activation accelerates the expression of matrix degrading enzymes. PAR-2 may play an important role in the cytokine-mediated catabolic cascade and consequently may be involved in IVD degeneration.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Expression of proteinase-activated receptor-2 in the intervertebral disc.2009
Author(s)
Iida, R., Akeda, K., Kasai, Y., Masuda, K., Morimoto, R., Sakakibara, T., Sato, M., Uchida, A.
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Journal Title
Spine (Phila Pa 1976) 34
Pages: 4-4
NAID
Related Report
Peer Reviewed
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[Journal Article] Thoracic myelopathy with alkaptonuria2008
Author(s)
Akeda, K., Kasai, Y., Kawakita, E., Matsumura, Y., Kono, T., Murata, T., Uchida, A.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Effect of osteogenic protein-1 on the matrix metabolism of boyine tendon cells2008
Author(s)
Yamada, M., Akeda, K., Asanu ma, K., Thonar, E. J., An, H. S., Uchida, A., Masuda, K
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Journal Title
J Orthop Res 26
Pages: 42-48
Related Report
Peer Reviewed
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