Biological effects of low-intensity pulsed ultrasound on the healing of fresh fractures and nonunions/delayed unions

• Project/Area Number: 20791036
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Kobe University
• Principal Investigator: NIIKURA Takahiro Kobe University, 医学部附属病院, 特命助教 (40448171)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 低出力超音波パルス / 骨折治療 / 骨折血腫 / 偽関節 / 新鮮骨折

Research Abstract

Biological mechanism how low-intensity pulsed ultrasound works on the healing of fresh fractures and nonunions/delayed unions was detected. This offered an evidence of using low-intensity pulsed ultrasound in the clinical field.

Research Products

• [Journal Article] Osteogenic activity of human fracture haematoma-derived progenitor cells is stimulated by low-intensity pulsed ultrasound in vitro. (2009)
  • Author(s): Hasegawa T, Miwa M, Sakai Y, Niikura T, Kurosaka M, Komori T.
  • Journal Title: J Bone Joint Surg Br. 91(2) Pages: 264-70
• [Journal Article] Osteogenic activities of human fracture haematoma-derived progenitor cells are stimulated by low intensity pulsed ultrasound in vitro (2009)
  • Author(s): Hasegawa T, Miwa M, Sakai Y, Niikura T, Kurosaka M, Komori T
  • Journal Title: J Bone Joint Surg Br 91 Pages: 264-270
  • Peer Reviewed
• [Presentation] 低出力超音波パルスはヒト偽関節細胞の骨分化能を促進する (2011)
  • Author(s): 古賀敬章, 他
  • Organizer: 第14回超音波骨折治療研究会
  • Place of Presentation: 東京ステーションコンファレンス(東京都)
  • Year and Date: 2011-01-22
• [Presentation] 低出力超音波パルスはヒト偽関節細胞の骨分化能を促進する (2011)
  • Author(s): 古賀敬章、李相亮、新倉隆宏、康暁博、堂垣佳宏、黒坂昌弘
  • Organizer: 第14回超音波骨折治療研究会
• [Presentation] 低出力超音波パルスとBMP-7によるヒト骨折血腫由来細胞の骨分化能への影響 (2010)
  • Author(s): 李相亮、新倉隆宏、三輪雅彦、康暁博、古賀敬章、黒坂昌弘
  • Organizer: 第13回超音波骨折治療研究会
  • Place of Presentation: 東京ステーションコンファレンス(東京都)
  • Year and Date: 2010-01-23
• [Presentation] 低出力超音波パルスはBMP-7によるヒト骨折血腫由来細胞の骨分化を促進する (2010)
  • Author(s): 李相亮、新倉隆宏、康暁博、古賀敬章、大江啓介、三輪雅彦、黒田良祐、黒坂昌弘
  • Organizer: 第25回日本整形外科学会基礎学術集会
• [Presentation] Effect of Low-Intensity Pulsed Ultrasound and BMP-7 on Osteogenic Differentiation of Human Fracture Hematoma-Derived Cells in Vitro. (2010)
  • Author(s): Lee SY, 新倉隆宏, 三輪雅彦, Koh A, 古賀敬章, Iwakura T, 岩倉崇, 黒坂昌弘
  • Organizer: 56th annual meeting of the Orthopaedic Research Society
• [Presentation] 低出力超音波パルスと Bone Morphogenetic Protein-7 (BMP-7)によるヒト骨折血腫由来細胞の 骨分化能への影響 (2010)
  • Author(s): 李相亮、新倉隆宏、三輪雅彦、康暁博、古賀敬章、黒坂昌弘
  • Organizer: 第13回超音波骨折治療研究会
• [Presentation] Effect of Low-Intensity Pulsed Ultrasound and BMP-7 on Osteogenic Differentiation of Human Fracture Hematoma-Derived Cells in Vitro (2010)
  • Author(s): Lee SY, Niikura T, Miwa M, Koh A, Koge T, Iwakura T, Kuroda R, Kurosaka M
  • Organizer: 56^<th> Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: New Orleans. LA, USA
• [Presentation] ヒト新鮮骨折において、低出力超音波パルス(LIPUS)は骨折血腫由来細胞の分化を促進し骨形成に作用する (2009)
  • Author(s): 岩倉崇、長谷川巧実、三輪雅彦、新倉隆宏、酒井良忠、大江啓介、李相亮、黒坂昌弘
  • Organizer: 第35回日本骨折治療学会
• [Presentation] 低出力超音波パルスはヒト骨折血腫由来細胞の分化を促進し骨形成に作用する (2009)
  • Author(s): 新倉隆宏、長谷川巧実、三輪雅彦、酒井良忠、大江啓介、李相亮、岩倉崇、康暁博、黒坂昌弘
  • Organizer: 第12回超音波骨折治療研究会
• [Presentation] Osteogenic activities of human fracture haematoma-derived progenitor cells are stimulated by low intensity pulsed ultrasound in vitro. (2009)
  • Author(s): Niikura T, Hasegawa T, Miwa M, Sakai Y, Oe K, Iwakura T, Koh A, Kurosaka M.
  • Organizer: 55th annual meeting of the Orthopaedic Research Society
• [Presentation] Osteogenic activities of human fracture haematoma-derived progenitor cells are stimulated by low intensity pulsed ultrasound in vitro (2009)
  • Author(s): Niikura T, Hasegawa T, Miwa M, Sakai Y, Oe K, Iwakura T, Koh A, Kurosaka M
  • Organizer: 55^<th> Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Las Vegas, NV, USA
• [Presentation] 低出力超音波パルスはヒトの骨折血腫由来細胞の分化を促進し骨形成に作用する (2009)
  • Author(s): 岩倉崇、長谷川巧実、三輪雅彦、新倉隆宏、酒井良忠、大江啓介、李相亮、黒坂昌弘
  • Organizer: 第35回日本骨折治療学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] ヒト新鮮骨折において、低出力超音波パルス(LIPUS)は骨折血腫細胞の骨分化を促進する (2008)
  • Author(s): 岩倉崇、長谷川巧実、三輪雅彦、新倉隆宏、酒井良忠、大江啓介、李相亮、黒坂昌弘
  • Organizer: 第23回日本整形外科学会基礎学術集会
• [Remarks] ホームページ等