Gene therapy in the treatment of ligament injury
| Project/Area Number |
20791040
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
FURUMATSU Takayuki Okayama University, 岡山大学病院, 助教 (20432651)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 靭帯組織再生 / 膝関節靭帯損傷 / 前十字靭帯(ACL) / 内側側副靭帯(MCL) / 遺伝子導入 / Scleraxis / Sox9 |
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| Research Abstract |
In our studies, combined treatment of bFGF, GDF-5, and peptide hydrogels stimulates the healing of rabbit MCL injury model. In addition, bFGF and GDF-5 play important roles in cellular migration and matrix synthesis of ligament-derived cells.
Scleraxis gene transduction using in vivo electroporation and sonoporation enhances the expression of type I collagen gene. Our results suggest that in vivo gene therapy might be a good candidate for the treatment of ligament injury.
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Report
(4 results)
Research Products
(61 results)
