Novel hybrid bone filling material of self-assembling peptide scaffold and artificial framework

• Project/Area Number: 20791041
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Okayama University
• Principal Investigator: MISAWA Haruo Okayama University, 岡山大学病院, 医員 (60448222)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 四肢機能再建学 / 骨再生 / 骨充填剤 / PEEK材 / SAPS / 複合素材 / 骨伝導性

Research Abstract

Bone filling materials should have enough strength for weight bearing and adequate osteoconductive property. But these properties are incompatible. In this study, we used hybrid materials of Self-assembling Peptide PuraMatrix and Polyetheretherketone Cage. PuraMatrix has good osteoconductive property and Polyetheretherketone Cage has enough strength for bone filing material. We showed that these hybrid materials were useful for repairing the bone defects in Rat's femurs.

Research Products

• [Journal Article] Bone repair by transplantation of hTERT-immortalized human mesenchymal stem cells in mice (2009)
  • Author(s): Hiroyuki Nakahara, Haruo Misawa, Takayuki Hayashi, et al
  • Journal Title: Transplantation 15;88(3) Pages: 346-53
  • Peer Reviewed
• [Journal Article] Bone Repair Using a Hybrid Scaffold of Self-assembling Peptide PuraMatrix and Polyetheretherketone Cage in Rats
  • Author(s): Hiroyuki Nakahara, Haruo Misawa, Takayuki Hayashi, Masato Tanaka, Aki Yoshida, Noriaki Tanaka, Toshifumi Ozaki, Naoya Kobayashi
  • Journal Title: Cell Transplantation (掲載予定)
  • Peer Reviewed
• [Journal Article] Bone Repair using a hybrid scaffold of self-assembling peptide PuraMatrix and polyetheretherketone cage in rats
  • Author(s): Hiroyoki Nakahara, Haruo Misawa, 他
  • Journal Title: Cell transplantation (in press)
  • Peer Reviewed
• [Presentation] 自己重合ペプチドスキャホールドに人工骨格を併用した骨充填剤によるラット大腿骨欠損の再生 (2009)
  • Author(s): 中原啓行、三澤治夫、林隆宏, ほか
  • Organizer: 第24回日本整形外科学会基礎学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2009-11-05
• [Presentation] 自己重合ペプチドスキャホールドに人工骨格を併用した骨充填剤によるラット大腿骨欠損の再生 (2008)
  • Author(s): 中原啓行、三澤治夫、林隆宏, ほか
  • Organizer: 第35回日本臓器保存生物医学会定期学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-23