Repair of meniscus using mesenchymal cells with magnetic targeting method

• Project/Area Number: 20791043
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Hiroshima University
• Principal Investigator: YAMASAKI Takuma Hiroshima University, 病院, 病院助教 (50444683)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 移植 / 再生医療 / 細胞 / 組織 / 移植・再生医療 / 細胞・組織

Research Abstract

Efficacy of intraarticular injection of mesenchymal cells (MSC) for meniscus injury was evaluated using MSC-magnetic beads complex in order to improve healing effect on injured meniscus. Firstly, MSC of Sprague-Dawley rats (SD rat) were injected into the knee of SD rats with injured meniscus. Secondary, human MSC were also injected into the knee of nude rats using the same protocol. However, no remarkable increase of extracellular matrices were observed by using the magnetic targeting method in the both models.