Expression of microRNA-146 in osteoarthritis cartilage

• Project/Area Number: 20791044
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Hiroshima University
• Principal Investigator: NAKASA Tomoyuki Hiroshima University, 病院, 病院助教 (60467769)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 病理学 / 再生医学 / 細胞 / 組織 / 生体分子臨床 / 細胞・組織 / 生体分子 / 臨床

Research Abstract

The aim of this study was to identify the expression pattern of microRNA-146 (miR-146) in osteoarthritis (OA) cartilage. MiR-146 is intensely expressed in low grade OA cartilage, especially in superficial zone. MiR-146 might play a role in OA cartilage pathogenesis.

Research Products

• [Journal Article] Expression of microRNA-146 in osteoarthritis cartilage (2009)
  • Author(s): Yamasaki K, Nakasa T, Miyaki S, Deie M, Adachi N, Yasunaga Y, Asahara H, Ochi M
  • Journal Title: Arthritis Rheum 60(4) Pages: 1035-41
  • Peer Reviewed
• [Journal Article] Expression of micro RNA-146 in osteoarthritis cartilage
  • Author(s): Keiichiro Yamasaki
  • Journal Title: Arthritis & Rheumatism (In press)
  • Peer Reviewed
• [Presentation] Expression of microRNA-146 in osteoarthritis cartilage (2008)
  • Author(s): Tomoyuki Nakasa
  • Organizer: 2008 ACR/ARHP Annual Scientific Meeting
  • Place of Presentation: San Fransisco, USA
  • Year and Date: 2008-10-28
• [Presentation] 変形性関節症軟骨におけるmicroRNA-146の発現 (2008)
  • Author(s): 山崎啓一郎
  • Organizer: 第23回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2008-10-24