| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We substituted damaged spinal cord in rats with chronic spinal cord injury for Collagen Filaments (CF). In addition, we impregnated with a Compound A which effected on the cell cycles and stimulated the repairs of tissues. In our vitro study, Compound A acted on the neural cells to promote mature differentiations. However, in vivo study, Compound A effected mainly on the Fibroblasts. So surroundings fibroblasts migrated across to the damaged spinal cord. In results, enough functional recovery were not shown in rats with chronic spinal cord injury. We think that additional ideas were necessary that genetically modified drugs etc effecting on neural cells specificity.
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