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A role of ectodomain shedding of RANK in osteoclastogenesis

Research Project

Project/Area Number 20791051
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKeio University

Principal Investigator

HAKOZAKI Akihiro  Keio University, 医学部, 研究員(非常勤) (10365299)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords破骨細胞 / receptor activator of NF-κB (RANK) / TACE / ADAM17 / ectodomain shedding / receptor activator of NF-KB (RANK) / recetor activator of NF-κB(RANK)
Research Abstract

We showed that receptor activator of NF-kB (RANK), one of the most essential molecules in osteoclastogenesis, is proteolytically cleaved and released from the cell surface. Furthermore, we found that that the cleavage of RANK is induced by binding to its cognitive ligand, RANKL, and that the ectodomain shedding of RANK potentially functions as a negative regulatory mechanism in osteoclastogenesis.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (8 results)

All 2010 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (6 results)

  • [Journal Article] Receptor Activator of NF-κB Ligand Induces Ectodomain Shedding of Receptor Activator of NF-κB in Murine RAW264. 7 Macrophages2010

    • Author(s)
      Hakozaki A, Yoda M, Tohmonda T, Furukawa M, Hikata T, Uchikawa S, Takaishi H, Matsumoto M, Chiba K, Horiuchi K, Toyama Y.
    • Journal Title

      The Journal of Immunology 184(5)

      Pages: 2442-2448

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Receptor Activator of NF-KB Ligand Induces Ectodomain Shedding of Receptor Activator of NF-KB in Murine RAW264.7 Macrophages2010

    • Author(s)
      Akihiro Hakozaki
    • Journal Title

      Journal of Immunology 184(5)

      Pages: 2442-2448

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] TNFa converting enzyme regulates proteolytic cleavage of receptor activator of NFk-B2009

    • Author(s)
      Akihiro Hakozaki
    • Organizer
      American Society for Bone and Mineral Research 2009 Annual Meeting
    • Place of Presentation
      Colorado Convention Center Denver.
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] RAW264.7細胞においてRANKL刺激はRANK sheddingを誘導する2009

    • Author(s)
      箱崎彰裕
    • Organizer
      第27回日本骨代謝学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] TNFαconverting enzyme regulates proteolytic cleavage of receptor activator of NFκ-B2009

    • Author(s)
      Akihiro Hakozaki, Keisuke Horiuchi, Tomohiro Hikata, Mitsuru Furukawa, Shinichi Uchikawa, Tomoaki Mori, Masaki Yoda, Takahide Tohmonda, Morio Matsumoto, Kazuhiro Chiba, Hironari Takaishi, Yoshiaki Toyama
    • Organizer
      ASBMR 2009 Annual Meeting
    • Place of Presentation
      Colorado Convention Center Denver
    • Related Report
      2009 Final Research Report
  • [Presentation] RAW264. 7細胞においてRANKL刺激はRANK sheddingを誘導する2009

    • Author(s)
      箱崎彰裕、堀内圭輔、依田昌樹、東門田誠一、日方智宏、内川伸一、古川満、松本守雄、高石官成、戸山芳昭
    • Organizer
      第27回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2009 Final Research Report
  • [Presentation] RANKはADAMI7によりsheddingを受け可溶型となる2008

    • Author(s)
      箱崎彰裕
    • Organizer
      第26回日本骨代謝学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] RANKはADAM17によりsheddingを受け可溶型となる2008

    • Author(s)
      箱崎彰裕、堀内圭輔、依田昌樹、東門田誠一、日方智宏、内川伸一、古川満、松本守雄、高石官成、戸山芳昭
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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