| Project/Area Number |
20791051
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
HAKOZAKI Akihiro Keio University, 医学部, 研究員(非常勤) (10365299)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 破骨細胞 / receptor activator of NF-κB (RANK) / TACE / ADAM17 / ectodomain shedding / receptor activator of NF-KB (RANK) / recetor activator of NF-κB(RANK) |
|---|
| Research Abstract |
We showed that receptor activator of NF-kB (RANK), one of the most essential molecules in osteoclastogenesis, is proteolytically cleaved and released from the cell surface. Furthermore, we found that that the cleavage of RANK is induced by binding to its cognitive ligand, RANKL, and that the ectodomain shedding of RANK potentially functions as a negative regulatory mechanism in osteoclastogenesis.
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