Establishment of a novel therapy using hepatocyte growth factor for spinal cord injury in primate

• Project/Area Number: 20791053
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Keio University
• Principal Investigator: KITAMURA Kazuya Keio University, 医学部, 助教 (00383860)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 脊髄損傷 / 再生医学 / 肝細胞増殖因子(HGF) / 治療 / 臨床応用 / HGF

Research Abstract

Intrathecal administration of recombinant human HGF significantly reduced damaged area in spinal cord and promoted motofunction recovery after spinal cord injury in common marmoset, non-human primate.

Research Products

• [Journal Article] 実験動物としてのコモンマーモセットと脊髄損傷モデル (2009)
  • Author(s): 北村和也、藤吉兼浩, 他
  • Journal Title: 分子細胞治療 8 Pages: 145-150
• [Journal Article] 神経生理学領域におけるマーモセットの有用性 (2008)
  • Author(s): 北村和也、岡野栄之
  • Journal Title: マーモセットMR脳アトラス Pages: 10-16
• [Presentation] ヒト組換えHGF蛋白を用いた脊髄損傷治療戦略 (2009)
  • Author(s): 北村和也, ら
  • Organizer: 日本整形外科学会基礎学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2009-11-05
• [Presentation] ヒト組み換えHGF蛋白を用いた脊髄損傷治療戦略 (2009)
  • Author(s): 北村和也、藤吉兼浩, 他
  • Organizer: 第24回日本整形外科学会基礎学術集会
  • Place of Presentation: 神奈川
  • Year and Date: 2009-11-05
• [Presentation] recombinant human Hepatocyte Growth Factorは霊長類脊髄損傷後の上肢運動機能回復を促進する-コモンマーモセットを用いた前臨床試験- (2009)
  • Author(s): 北村和也, ら
  • Organizer: 日本脊椎脊髄病学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-04-23
• [Presentation] rhHGFは霊長類脊髄損傷後の上肢運動機能回復を促進する : コモンマーモセットを用いた前臨床試験 (2009)
  • Author(s): 北村和也、藤吉兼浩, 他
  • Organizer: 第8回日本再生医療学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-06
• [Presentation] Practical implementation of feasible regenerative medicine-Intrathecal administration of recombinant human hepatocyte growth factor promotes functional recovery after spinal cord iniurv ; pre-clinical trial using common marmoset (2009)
  • Author(s): Kitamura K
  • Organizer: ハイテクリサーチセンター整備事業再生医学・治療研究開発センタープロジェクト, グローバルCOEプログラム「幹細胞医学のための教育研究拠点」共催シンポジウム2009 Forefront of the regenerative medicine
  • Place of Presentation: 東京
  • Year and Date: 2009-01-23
• [Presentation] Intrathecal administration of recombinant human hepatocyte growth factor promotes recovery of hand dexterity after cervical spinal cord injury in primate: Preclinical trial using common marmoset (2009)
  • Author(s): Kazuya Kitamura, et al
  • Organizer: Cervical Spine Research Society European Section
  • Place of Presentation: Uppsala, Sweden
• [Presentation] Intrathecal administration of recombinant human hepatocyte growth factor promotes recovery of hand dexterity after cervical spinal cord injury in primate : Preclinical trial using common marmoset (2009)
  • Author(s): Kitamura K, Fujiyoshi K., et.al.
  • Organizer: 55^<th> Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Las Vegas, Nevada, USA
• [Presentation] Therapeutic Strategy Using Hepatocyte Growth Factor ; from Rodent to Ptimate (2008)
  • Author(s): Kitamura K
  • Organizer: Joint Symposium of three Global COEs. "Evolution of Human Brain"
  • Place of Presentation: 東京
  • Year and Date: 2008-11-28
• [Presentation] Hepatocyte Growth Factorは損傷脊髄の内在性修復および運動機能回復を促進する ; げっ歯類から霊長類へ臨床応用へ向けて (2008)
  • Author(s): 北村和也、申村雅也, 他
  • Organizer: 第31回日本神経科学会
  • Place of Presentation: 東京
• [Presentation] Hepatocyte Growth Factor Promotes Endogenous Repair and Functional Recovery after Spinal Cord Injury ; Preclinical Trial from Rodents to Primates (2008)
  • Author(s): Kitamura K, Okano H
  • Organizer: The 3^<rd> International Conference of Neurons and Brain Diseases
  • Place of Presentation: Seoul, Korea
• [Presentation] Therapeutic Treatment for Spinal Cord Injury ; the latest research, strategies and visions (2008)
  • Author(s): Kitamura K
  • Organizer: USP/KEIO International Symposium for the Celebration of the Japanese Centennial Immigration to Brazil and the Sesquicentennial Anniversary of KEIO University
  • Place of Presentation: San Paulo, Brazil
• [Presentation] 脊髄損傷に対するrecombinant humanHepatocyte Growth Factor(rhHGF)の有効性の検討 (2008)
  • Author(s): 北村和也、中村雅也, 他
  • Organizer: 第23回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都
• [Presentation] Hepatocyte growth factor(HGF)は脊髄損傷後反応性アストロサイトの遊走を促進する (2008)
  • Author(s): 北村和也、中村雅也, 他
  • Organizer: 第23回賃本整形外科学会基礎学術集会
  • Place of Presentation: 京都
• [Presentation] Intrathecal administration of recombinant human hepatocyte growth factor promotes functional recovery after spinal cord injury ; pre-clinical trial using common marmoset (2008)
  • Author(s): Kitamura K, Fujiyoshi K., et.al.
  • Organizer: Neuroscience 2008(SFN)
  • Place of Presentation: Washington D.C., USA