Establishment of cell therapy for transplanting neural crest-derived stem cells into spinal cord injury model of rodent and mammalian
| Project/Area Number |
20791054
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
NAGOSHI Narihiro Keio University, 医学部, 助教 (10383837)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 再生医療 / 脊髄損傷 / 細胞移植 / 神経堤幹細胞 / 霊長類 / 神経堤 / 後根神経節 / 皮膚 / 骨髄 / 胚葉転換 |
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| Research Abstract |
Neural crest-derived stem cells (NCSCs) are isolated from adult skin and bone marrow, and they have the ability to differentiate into neural cells. Therefore, NCSCs are expected as cell sources for transplantation into spinal cord injury. In our study, we transplanted NCSCs into spinal cord injury model of mice. We observed the transplanted NCSCs surviving in the injured spinal cord, differentiating into neural cells. Moreover, the transplanted NCSCs had no tumorigenesis, suggesting that transplantation of NCSCs are safe. We also isolated and characterized NCSCs from adult marmoset or human skin.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Prospective identification, isolation and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow2009
Author(s)
Morikawa S, Mabuchi Y, Kubota Y, Nagai Y, Niibe K, Hiratsu E, Suzuki S, Miyauchi-Hara C, Nagoshi N, Sunabori T, Shimmura S, Miyawaki A, Nakagawa T, Suda T, Okano H, Matsuzaki Y.
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Journal Title
Journal of Experimental Medicine 206
Pages: 2483-2496
Related Report
Peer Reviewed
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[Journal Article] Development of mesenchymal stem cells partially originate from neural crest2009
Author(s)
Morikawa S, Mabuchi Y, Niibe K, Suzuki S, Nagoshi N, Sunabori T, Shimmura S, Nagai Y, Nakagawa T, Okano H, Matsuzaki Y.
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Journal Title
Biochemical and Biophysical Research Communications 379
Pages: 1114-1119
Related Report
Peer Reviewed
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[Journal Article] ES cell-derived NS/PCs transplantation after spinal cord injury2009
Author(s)
Kumagai G, Okada Y, Yamane J, Nagoshi N, Kitamura K, Mukaino M, Tsuji O, Fujiyoshi K, Katoh H, Okada S, Shibata S, Matsuzaki Y, Toh S, Toyama Y, Nakamura M, Okano H.
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Journal Title
Related Report
Peer Reviewed
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