Analysis of IL-27 receptor deficient mouse induced by inflammatory bone destruction model

• Project/Area Number: 20791055
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Keio University
• Principal Investigator: FURUKAWA Mitsuru Keio University, 医学部, 助教 (70468502)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: シグナル伝達 / 免疫学 / 発生・分化 / IL-27 / サイトカイン / 炎症性骨破壊 / WSX-1 / 骨免疫 / 破骨細胞 / ヒト / STAT1

Research Abstract

hIL-27 acts as an anti-inflammatory cytokine in human bone destruction, by inhibiting osteoclastogenesis from hCFU-GMs via STAT1-dependent down-regulation of the transcription factor c-Fos.

Research Products

• [Journal Article] IL-27 Abrogates Receptor Activator of NF-kB Ligand-Mediated Osteoclastogenesis of Human.Granulocyte-Macrophage Colony-Forming Unit Cells through STAT1-Dependent Inhibition of c-Fos. (2009)
  • Author(s): Furukawa M, Takaishi H, Takito J, Yoda M, Sakai S, Hikata T, Hakozaki A, Uchikawa S, Matsumoto M, Chiba K, Kimura T, Okada Y, Matsuo K, Yoshida H, Toyama Y.
  • Journal Title: J Immunol 15;183(4) Pages: 2397-2406
  • Peer Reviewed
• [Journal Article] IL-27 Abrogates Receptor Activator of NF-kB Ligand-Mediated Osteoclas togenesis of Human Granulocyte-Macrophage Colony-Forming Unit Cells throueh STAT1-Denendent Inhibition of c-Fos. (2009)
  • Author(s): Mitsuru Furukawa
  • Journal Title: J Immunol 15;183(4) Pages: 2397-2406
  • Peer Reviewed
• [Presentation] Foxp3+ Regulatory T cell deficiency induces osteosclerosis via hyperactivation of osteoclast-suppressive (2009)
  • Author(s): Furukawa,Takaishi,Sakai,Tohmonnda, Yoda,Yoshida
  • Organizer: CD4+T cell subsets ASBMR
  • Place of Presentation: Colorado Convention Center
  • Year and Date: 2009-09-14
• [Presentation] IRAK-4 enhances RANKL-mediated osteoclast maturation and survival through via IL-1-dependent NF-kB signaling ASBMR (2009)
  • Author(s): Furukawa,Takaishi,Sakai,Tohmonnda, Yoda,Yoshida
  • Organizer: Poster Session II on Sunday, September 13, 2009
  • Place of Presentation: Colorado Convention Center
  • Year and Date: 2009-09-13
• [Presentation] IL-27 Abrogates RANKL-mediated Osteoclastogenesis of Human Granulocyte Macrophage CFU Cells through STAT1-dependent Inhibition of c-Fos ASBMR (2009)
  • Author(s): Furukawa,Takaishi,Sakai,Tohmonnda, Yoda,Yoshida
  • Organizer: Welcome Reception and Plenary Poster Session on Friday
  • Place of Presentation: Colorado Convention Center
  • Year and Date: 2009-09-11
• [Presentation] IRAK-4 はIL-1 依存性のNF-κB シグナルを介して、骨芽細胞におけるRANKL 発現および破骨細胞の成熟・延命を促進する (2009)
  • Author(s): 古川、高石、坂井、東門田、依田、吉田、戸山
  • Organizer: 日本整形外科学会基礎学術集会
  • Place of Presentation: 横浜
• [Presentation] IRAK-4 はIL-1 依存性のNF-κB シグナルを介して、骨芽細胞におけるRANKL 発現および破骨細胞の成熟・延命を促進する (2009)
  • Author(s): 古川、高石、坂井、東門田、依田、吉田、戸山
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 大阪
• [Presentation] Foxp^<3+> Regulatory T cell deficiency induces osteosclerosis via hyperactivation of osteoclast-suppressive CD4+T cell subsets (2009)
  • Author(s): Mitsuru Furukawa
  • Organizer: ASBMR
  • Place of Presentation: Denver Colorado
• [Presentation] IL-27 Abrogates RANKL-mediated Osteoclastogenesis of Human Granulocyte-Macrophage CFU Cells through STAT1-dependent Inhibition of c-Fos (2009)
  • Author(s): Mitsuru Furukawa
  • Organizer: ASBMR
  • Place of Presentation: Denver Colorado
• [Presentation] IRAK-4 enhances RANKL-mediated osteoclast maturation and survival through via IL-1-dependent NF-kB signaling (2009)
  • Author(s): Mitsuru Furukawa
  • Organizer: ASBMR
  • Place of Presentation: Denver Colorado
• [Presentation] IL-27/WSX-1シグナルはLPS刺激によって誘導され、RANKL依存性の破骨細胞形成をSTAT1の活性化を介して抑制する (2009)
  • Author(s): 古川満
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 大阪
• [Presentation] IL-27/WSX-1シグナルはLPS刺激によって誘導され、NKL依存性の破骨細胞形成をSTAT1の活性化を介して抑制する (2009)
  • Author(s): 古川満
  • Organizer: 日本整形外科学会基礎
  • Place of Presentation: 横浜
• [Presentation] IL-27/WSX-1 シグナルはLPS 刺激によって誘導され、RANKL 依存性の破骨細胞形成をSTAT1 の活性化を介して抑制する (2008)
  • Author(s): 古川、高石、坂井、東門田、依田、吉田、戸山
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 大阪(口頭発表)
• [Presentation] IL-27 Abrogates RANKL-mediated Osteoclastogenesis from Human Granulocyte-macrophage Colony-forming Unit derived Cells through STAT1-Dependent Inhibition of c-Fos (2008)
  • Author(s): Furukawa,Takaishi,Sakai,Tohmonnda ,Yoda,Toshida
  • Organizer: ASBMR
  • Place of Presentation: Canada(Poster presentation)
• [Presentation] IL-27 Abrogates RANKL-mediated Osteoclastogenesis from Human Granulocyte-macrophage Colony-forming Unit derived Cells through STAT1-Dependent Inhibition of c-Fos. Conference (2008)
  • Author(s): Furukawa,Takaishi,Sakai,Tohmonnda, Yoda,Yoshida
  • Organizer: 2nd Osteoimmunology
  • Place of Presentation: Rhodes in Greece(Oral presentation)
• [Presentation] インターロイキン27の破骨細胞における役割 (2008)
  • Author(s): 古川満
  • Organizer: 第26回日本骨代謝学会
  • Place of Presentation: 大阪
• [Presentation] インターロイキン27の破骨細胞における役割 (2008)
  • Author(s): 古川満
  • Organizer: 第23回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都
• [Presentation] IL-27 Abrogates RANKL-mediated Osteoclastogenesis of Human Granulocyte-Macrophage CFU Cells through STAT1-dependent Inhibition of c-Fos (2008)
  • Author(s): 古川満
  • Organizer: 2^<nd> Osteoimmunology
  • Place of Presentation: Rhodes, Greece
• [Presentation] IL-27 Abrogates RANKL-mediated Osteoclastogenesis of Human Granulocyte-Macrophage CFE Cells through STAT1-dependent Inhibition of c-Fos (2008)
  • Author(s): 古川満
  • Organizer: ASBMR
  • Place of Presentation: Montreal, Canada