Isolation and characterization of a novel peptide from gastrointenstinal tract associated with osteoblast differentiation and bone formation

Research Project

Project/Area Number	20791058
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Orthopaedic surgery
Research Institution	Kurume University
Principal Investigator	FUKUSHIMA Nobuhiro Kurume University, 医学部, 助教 (90412535)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000) Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	ペプチド / 骨芽細胞 / 分化 / 骨密度 / 消化管 / カルシウム
Research Abstract	We discovered a novel peptide which is a positive regulator that acts directly on osteoblasts. This peptide directly promotes osteoblast differentiation in vitro and increases bone mineral density in vivo. The discovery of novel peptide may provide a new treatment option for osteoporosis and fracture healing.