The physiological function of RAMP whose expression is enhanced during embryogenesis and muscle regeneration.
Project/Area Number |
20791059
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Orthopaedic surgery
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Research Institution | Kumamoto University |
Principal Investigator |
NAKAYAMA Yuki Kumamoto University, 大学院・先導機構, 特定事業教員 (30332381)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 筋ジストロフィー / 筋再生 / マウス / 細胞外マトリックス / 骨格筋 / 筋ジストロフー / 発生過程 |
Research Abstract |
The aim of this study is to investigate the physiological function of RAMP whose expression is enhanced in skeletal muscles after injury. To elucidate the function of RAMP, I conducted a yeast two-hybrid screen to identify its interacting partners and isolated 7 clones. Furthermore, to elucidate the physiological function of RAMP in regenerating muscle, I started to produce the mice conditionally inactivated RAMP in skeletal muscle.
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Report
(3 results)
Research Products
(8 results)