The physiological function of RAMP whose expression is enhanced during embryogenesis and muscle regeneration.

• Project/Area Number: 20791059
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Kumamoto University
• Principal Investigator: NAKAYAMA Yuki Kumamoto University, 大学院・先導機構, 特定事業教員 (30332381)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 筋ジストロフィー / 筋再生 / マウス / 細胞外マトリックス / 骨格筋 / 筋ジストロフー / 発生過程

Research Abstract

The aim of this study is to investigate the physiological function of RAMP whose expression is enhanced in skeletal muscles after injury. To elucidate the function of RAMP, I conducted a yeast two-hybrid screen to identify its interacting partners and isolated 7 clones. Furthermore, to elucidate the physiological function of RAMP in regenerating muscle, I started to produce the mice conditionally inactivated RAMP in skeletal muscle.

Research Products

• [Journal Article] Antibody-assisted enhancement of biological activities of CXCL14 in human monocytic leukemia-derived THP-1 cells and high fat diet-induced obese mice. (2010)
  • Author(s): Tanegashim, Suzuki, Nakayama, et., al.
  • Journal Title: Experimental Cell Research 316 Pages: 1263-1270
  • Peer Reviewed
• [Journal Article] CXCL14 and insulin action (2009)
  • Author(s): Hara T., Nakayama Y.
  • Journal Title: Vitamins and Hormones 80 Pages: 107-123
  • Peer Reviewed
• [Journal Article] Promotion of spermatogonial proliferation by neuregulin 1 in newt (Cynops pyrrhogaster) testis (2008)
  • Author(s): Oral O., Uchida I., Eto K., Nakayama Y., Nishimura O., Hirao Y., Ueda J., Tarui H., Agata K. Abe S.
  • Journal Title: Mech Dev 125(9-10) Pages: 906-917
  • Peer Reviewed
• [Journal Article] Promotion of spermatogonial proliferation by neuregulin 1 in newt (Cynopspyrrhogaster) testis (2008)
  • Author(s): Oral O.
  • Journal Title: Mechanisms of Development 125 Pages: 906-917
  • Peer Reviewed
• [Presentation] The expression and function of Brinp3 during skeletal muscle regeneration (2009)
  • Author(s): 中山由紀、原孝彦
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-11
• [Presentation] The expression and function of Brinp3 during skeletal muscle regeneration. (2009)
  • Author(s): 中山由紀
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜 パシフィコ横浜
  • Year and Date: 2009-12-11
• [Remarks]
  • URL: http://sendou.kuma-u.jp/research/nakayama.html
• [Patent(Industrial Property Rights)] 抗BRAK (CXCL14)ヒトモノクローナル抗体及びその用途 (2008)
  • Inventor(s): 原孝彦、寺沢(中山)由紀、波佐間正聡
  • Industrial Property Rights Holder: 東京都医学研究機構原孝彦、寺沢(中山)由紀
  • Filing Date: 2008-12-02