| Project/Area Number |
20791060
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Hokkaido University |
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Principal Investigator |
TACHIBANA Kaori Hokkaido University, 北海道大学病院, 医員 (50374468)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 疼痛管理学 / 神経因性疼痛 / 前帶状回 / 電気生理 / 抗うつ薬 / in vivo / シナプス伝達効率 / シナプス可塑性 / 疼痛 / 前帯状回 |
|---|
| Research Abstract |
Neuropathic pain caused significant suppression of EPSPs in the ACC compared with rats subjected to sham surgery without altering the paired-pulse responses. These findings suggest that the alterations in EPSPs were not attributable to the presynaptic site of action. This abnormal excitability of the ATN-ACC synapse may be important in understanding the mechanism underlying neuropathic pain, particularly with respect to the affective and cognitive aspects.
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