The preparation of control-released local anesthetics and clinical use for clonic pain therapy.

• Project/Area Number: 20791065
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Gunma University
• Principal Investigator: TOBE Masaru Gunma University, 医学部, 助教 (90400770)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 徐放薬 / 疼痛治療 / 局所麻酔薬 / ポリ乳酸 / 術後痛 / c-fos

Research Abstract

We created a novel slow-release lidocaine sheet with polylactic-co-glycolic acid. Single sciatic nerve block with slow-release lidocaine inhibited hypersensitivity after paw incision. Spinal cord dorsal horn c-fos expression was consistent with the behavioral results. Slow-release local anesthetics are promising for management of postoperative pain.

Research Products

• [Journal Article] Long-term effect of sciatic nerve with slow-release lidocaine in a rat model of postoperative pain. (2010)
  • Author(s): Masaru Tobe, Hideaki Obata, Takashi Suto, Hideaki Yokoo, Yoichi Nakazato, Yasuhiko Tabata, Shigeru Saito
  • Journal Title: Anesthesiology 112(6) Pages: 1473-1481
  • Peer Reviewed
• [Journal Article] Long-term effect of sciatic nerve block with slow-release lidocaine in a rat model of postoperative pain. (2010)
  • Author(s): 戸部賢
  • Journal Title: Anesthesiology Volume: 112(6) Pages: 1473-81
  • Peer Reviewed
• [Presentation] リドカイン徐放薬の毒性と臨床応用への可能性 (2010)
  • Author(s): 戸部賢
  • Organizer: 第57回日本麻酔科学会
  • Place of Presentation: 福岡国際会議場・マリンメッセ(福岡市)
  • Year and Date: 2010-06-04
• [Presentation] リドカイン徐放薬の毒性と臨床応用への可能性 (2010)
  • Author(s): 戸部賢
  • Organizer: 第57回日本麻酔科学会
  • Place of Presentation: マリンメッセ福岡
  • Year and Date: 2010-06-04
• [Presentation] A long-term effect of sciatic nerve block with slow releasing lidocaine in a rat model of postoperative pain (2009)
  • Author(s): 戸部賢
  • Organizer: Society for Neuroscience 39^<th> annual meeting
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2009-10-19
• [Presentation] リドカイン徐放薬の作成と疼痛治療への応用 (2008)
  • Author(s): 戸部賢
  • Organizer: 第55回日本麻酔科学会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2008-06-14
• [Presentation] リドカイン徐放薬の作成と疼痛治療への応用 (2008)
  • Author(s): 戸部賢
  • Organizer: 第55回日本麻酔科学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-06-14