| Project/Area Number |
20791068
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
J・P Bellier Shiga University of Medical Science, 分子神経科学研究センター, 助教 (80346022)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | アセチルコリン / acetylcholine / 後根神経節 / dorsal root ganglion / pChAT / pain / 神経障害痛モデルラット / rat neuropathic pain model / 神経障害痛のラットモデル / neuropathic pain model |
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| Research Abstract |
The presence of a splice variant of the enzyme choline acetyltransferase (pChAT) has been demonstrated in the dorsal root ganglion neurons. The role of acetylcholine synthesized by pChAT in DRG has been investigated in rat model of neuropathic pain with the use of agonist of cholinergic system. Ours experimental results suggest that a cholinergic regulation of nociception take place at the level of primary sensory neurons. Moreover cholinergic marker was investigated in human DRG. Our results suggest that pChAT might be a relevant target for analgesia in human.
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