The role of neutrophil elastase in the development of neuronal damage following transient forebrain ischemia.
| Project/Area Number |
20791076
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Yamaguchi University |
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Principal Investigator |
HIRATA Takao Yamaguchi University, 医学部附属病院, 助教 (40420533)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 蘇生学 / 好中球エラスターゼ / 脳保護 / 一過性前脳虚血 / 海馬CA1 / 細胞外マトリックス / カスパーゼ |
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| Research Abstract |
The present study suggests that neutrophil elastase possibly, but may not exclusively, derived from activated leukocytes contributes to the development of selective neuronal death in hippocampal CA1 after 8 min-forebrain ischemia in rats and that a specific neutrophil elastase inhibitor, ONO-5046, ameliorates neuronal damage via inhibition of neutrophil elastase distribution in the extracellular matrix after ischemia. Further study may be needed to determine the therapeutic time window for ONO-5046 and the effects of higher or repeated doses as well as the detailed mechanisms for interaction between neutrophil elastase and activation of caspase.
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Report
(3 results)
Research Products
(5 results)
