Analysis of lipid microdomain under volatile anesthesia

• Project/Area Number: 20791078
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kagawa University
• Principal Investigator: ONO Junichiro Kagawa University, 医学部附属病院, 助教 (90363217)
• Research Collaborator: SUZUKI Shingo 東京医科歯科大学, 難治疾患研究所, 特任講師 (50451430)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 麻酔学 / 揮発性麻酔薬 / 作用機序 / マイクロドメイン / 麻酔メカニズム / 脂質 / シグナル伝達

Research Abstract

Microdomain in lipid bilayer may contribute to the mechanisms of volatile anesthesia. Isoflurane upregulated amount of cholesterol and protein contained in microdomain fraction extracted from mice brain. Total protein was particularly increased in isoflurane anesthesia.