Administration of the Rho-kinase inhibitor Fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine.

• Project/Area Number: 20791079
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Nagasaki University
• Principal Investigator: SHIBATA Itsuko Nagasaki University, 病院, 助教 (10404245)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 心筋虚血再灌流障害 / 心筋スタニング / Rho-kinase阻害薬 / 薬理学的プレコンディショニング / ポストコンディショニング / PDEIII阻害薬 / 薬理学的ポストコンディショニング

Research Abstract

We assessed the effect of administration time for fasudil treatment of the stunned myocardium in 40 anesthetized open chest swine. Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in anesthetized open-chest swine. This cardioprotective effect of fasudil against myocardial stunning was probably not related to systemic or coronary hemodynamic changes. Rho-kinase inhibition during early reperfusion could therefore protect against myocardial stunning.

Research Products

• [Journal Article] Administration of the Rho-kinase inhibitor Fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine. (2008)
  • Author(s): Itsuko Shibata, Osamu Yoshitomi, Tadasuke Use, Hiroyuki Ureshino, Sungsam Cho, Takuji Maekawa, Tetsuya Hara, Koji Sumikawa
  • Journal Title: Cardiovascular drugs and therapy 22 Pages: 293-298
  • NAID: 120006983692
  • Peer Reviewed
• [Journal Article] Administration of the Rho-kinase inhibitor Fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine (2008)
  • Author(s): Itsuko Shibata
  • Journal Title: Cardiovascular drugs and therapy 22 Pages: 293-298
  • NAID: 120006983692
  • Peer Reviewed
• [Presentation] ホスホジエステラーゼIII阻害薬ミルリノンの投与時間がブタのスタン心筋の回復に与える影響 (2009)
  • Author(s): 柴田伊津子
  • Organizer: 日本麻酔科学会第56回学術集会
  • Place of Presentation: 神戸市
• [Presentation] Milrinone Administered just after but not 20 min after reperfusion protects against myocardial stunning in swine (2009)
  • Author(s): Itsuko Shibata
  • Organizer: 16th Asean Congress of Anaesthesiologists
  • Place of Presentation: Kota Kinabalu (Malaysia)
• [Presentation] Milrinone Administered Just After but not 20 min After Reperfusion Protects against Myocardial Stunning in Swine (2009)
  • Author(s): Itsuko Shibata
  • Organizer: 16^<th> Asean Congress of Anaesthesiologists
  • Place of Presentation: Kota Kinabalu (Malaysia)
• [Presentation] ホスホジエステラーゼIII阻害薬ミルリノンの投与時間がブタのスタン心筋の回復に与える影響 (2009)
  • Author(s): 柴田伊津子
  • Organizer: 日本麻酔科学会 第56回学術集会
  • Place of Presentation: 神戸市
• [Remarks] 長崎大学各術研究成果リポジトリ
  • URL: http://hdl.handle.net/10069/22594