Pathosis and control of splanchnic circulation in septic shock

• Project/Area Number: 20791080
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Nagasaki University
• Principal Investigator: SEKINO Motohiro Nagasaki University, 病院, 助教 (40380927)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 敗血症性ショック / 腸管循環カ / ルペリチド / 腸管循環 / カルペリチド

Research Abstract

In porcine fluid-resuscitated endotoxemia model, a low dose of carperitide, a synthetic atrial natriuretic peptide, administered prior to endotoxemia maintained systemic and splanchnic circulation, and prevented the deterioration of oxygenation. Carperitide infusion is a potentially beneficial therapy with respect to systemic and splanchnic circulation as well as the respiratory system during sepsis.

Research Products

• [Journal Article] Synthetic atrial natriuretic peptide improves systemic and splanchnic circulation and has a lung-protective effect during endotoxemia in pigs. (2010)
  • Author(s): Sekino M, Makita T, Ureshino H, Cho S, Sumikawa K
  • Journal Title: Anesth Analg 110(1) Pages: 141-147
  • Peer Reviewed
• [Journal Article] Synthetic Atrial Natriuretic Peptide Improves Systemic and Splanchnic Circulation and Has a Lung-Protective Effect During Endotoxemia in Pigs (2010)
  • Author(s): Motohiro Sekino
  • Journal Title: Anesthesia & Analgesia 110 Pages: 141-147
  • Peer Reviewed
• [Presentation] 急性呼吸不全発症時の肺血管外水分量および肺血管透過性指数と人工呼吸期間および予後との関連性の検討 (2011)
  • Author(s): 中村利秋
  • Organizer: 第38回日本集中治療医学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-26
• [Presentation] ペースメーカーリード感染により上大静脈狭窄を呈した肝部下大静脈欠損症の1例 (2011)
  • Author(s): 酒井亜輝子
  • Organizer: 第38回日本集中治療医学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-25
• [Presentation] 子宮ガス壊疽から敗血症性ショックに至った一例 (2011)
  • Author(s): 関野元裕
  • Organizer: 第38回日本集中治療医学会学術集会
  • Year and Date: 2011-03-24
• [Presentation] Septic shockとして初療開始したが、既存の副腎不全合併が考えられた1症例 (2011)
  • Author(s): 中村利秋
  • Organizer: 第38回日本集中治療医学会学術集会
  • Year and Date: 2011-03-24
• [Presentation] 心・大血管手術後の難治性頻脈に関わる因子について-塩酸ランジオロール使用量からの検討- (2011)
  • Author(s): 吉富修
  • Organizer: 第38回日本集中治療医学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-24
• [Presentation] ブタエンドトキシン血症モデルにおけるカルペリチドの有用性 (2010)
  • Author(s): 関野元裕
  • Organizer: 第84回日本感染症学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-04-06
• [Presentation] ブタエンドトキシン血症におけるカルペリチドの有用性 (2010)
  • Author(s): 関野元裕
  • Organizer: 第84回日本感染症学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-04-06
• [Presentation] A New Technique for Post-Pyloric Feeding Tube Placement by Palpation in Critically Ill Patients (2010)
  • Author(s): 関野元裕
  • Organizer: 第37回日本集中治療医学会学術集会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-05
• [Presentation] A new technique for post-pyloric feeding tube placement by palpation in critically ill patients. (2009)
  • Author(s): Motohiro Sekino.
  • Organizer: The ASA Annual Meetig
  • Place of Presentation: New Orleans
  • Year and Date: 2009-10-19
• [Presentation] A New Technique for Post-Pyloric Feeding Tube Placement by Palpation in Critically Ill Patients (2009)
  • Author(s): Motohiro Sekino
  • Organizer: 米国麻酔学会
  • Place of Presentation: ニューオリンズ
  • Year and Date: 2009-10-19
• [Presentation] 脾摘後重症感染症(overwhelming postsplenectomy infection : OPSI)の1症例 (2009)
  • Author(s): 関野元裕
  • Organizer: 第19回集中治療学会九州地方会
  • Place of Presentation: 大分
  • Year and Date: 2009-07-04
• [Presentation] Atrial natriuretic peptide improves pulmonary circulation and function during endotoxemia in pigs. (2009)
  • Author(s): Tetsuji Makita.
  • Organizer: Euroanaesthesia 2009
  • Place of Presentation: Milan, Italy
  • Year and Date: 2009-06-06
• [Presentation] 肺内水分動態と予後に関する検討-定量的モニタリングの意義- (2009)
  • Author(s): 中村利秋
  • Organizer: 日本集中治療学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-02-28
• [Presentation] デクスメデトミジン長期投与終了後の血行動態についての検討 (2009)
  • Author(s): 津田敦
  • Organizer: 日本集中治療学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-02-26
• [Presentation] 肺内水分動態の定量的モニタリングが有用であった急性呼吸不全を呈した食道穿孔・膿胸の-症例 (2009)
  • Author(s): 中村利秋
  • Organizer: 日本集中治療学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-02-26
• [Presentation] 両側膿胸を合併したLemierre症候群の1例 (2009)
  • Author(s): 吉冨修
  • Organizer: 日本集中治療学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-02-26
• [Presentation] 塩酸ピルジカイニドおよびコハク酸シベンゾリン中毒による循環不全と意識障害を来たし集中治療を要した-症例 (2008)
  • Author(s): 関野元裕
  • Organizer: 日本集中治療学会九州地方会
  • Place of Presentation: 熊本
  • Year and Date: 2008-07-05