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The protective effect of hydrogen on myocardial ischemia-reperfusion injury

Research Project

Project/Area Number 20791082
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionOita University

Principal Investigator

KOGA Hironori  Oita University, 医学部, 医員 (50468013)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords蘇生学 / 心筋虚血再灌流障害 / 水素 / 心筋虚血 / フリーラジカル / 電子スピン共鳴
Research Abstract

Recently, some researchers have reported that hydrogen gas has free radical scavenging effect, and they have been trying to apply hydrogen in a clinical setting as an antioxidant. In the present study, we have established methods of administering hydrogen to the body safely and appropriately, moreover, we have found that hydrogen ameliorates renal ischemia-reperfusion injury. These results have indicated that even low dose of hydrogen can produce an antioxidant effect, which has shown great potential for clinical use of hydrogen.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (8 results)

All 2010 2009

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (3 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Hydrogen-Rich Saline Solution Attenuates Renal Ischemia-reperfusion Injury.2010

    • Author(s)
      C.Shingu, H.Koga, S.Hagiwa, S.Matsumoto, K.Goto, I.Yokoi, T.Noguchi.
    • Journal Title

      Journal of Anesthesia 24(4)

      Pages: 569-574

    • NAID

      10026632638

    • Related Report
      2010 Final Research Report
  • [Journal Article] Hydrogen-Rich Saline Solution Attenuates Renal Ischemia-reperfusin injury2010

    • Author(s)
      C.Shingu, H.Koga, S.Hagiwa, S.Matsumoto, K.Goto, I.Yokoi, T.Noguchi
    • Journal Title

      Journal of Anesthesia

      Volume: 24(4) Pages: 569-74

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen-Rich Saline Solution Attenuates Renal Ischemia-reperfusin injury2010

    • Author(s)
      C.Shingu, H.Koga, S.Hagiwa, S.Matsumoto, K.Goto, I.Yokoi, T.Noguchi
    • Journal Title

      Journal of Anesthesia (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Hydrogen-Rich Saline Attenuates Renal Ischemia-Reperfusion Injury in a Rodent Model2010

    • Author(s)
      Hironori Koga, 他
    • Organizer
      Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      San Diego, California
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hydrogen-Rich Saline Attenuates Renal Ischemia?Reperfusion Injury in a Rodent Model2010

    • Author(s)
      Hironori Koga, 他5名
    • Organizer
      Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      17San Diego, California
    • Related Report
      2010 Final Research Report
  • [Presentation] 水素水静脈内持続投与による腎虚血再灌流障害の改善効果2009

    • Author(s)
      加藤喜久、古賀寛教、萩原聡, 他4名
    • Organizer
      九州麻酔科学会
    • Place of Presentation
      長崎
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 水素投与装置2009

    • Inventor(s)
      野口隆之、萩原 聡、古賀寛教
    • Industrial Property Rights Holder
      大分大学
    • Industrial Property Number
      2009-141875
    • Filing Date
      2009-06-15
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 水素投与装置2009

    • Inventor(s)
      野口隆之、古賀寛教、萩原聡
    • Industrial Property Rights Holder
      大分大学
    • Industrial Property Number
      2009-141875
    • Filing Date
      2009-06-15
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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