| Project/Area Number |
20791085
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
SUGINO Shigekazu Sapporo Medical University, 医学部, 助教 (00423765)
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| Research Collaborator |
NAMIKI Akiyoshi 札幌医科大学, 医学部, 名誉教授
HAYASE Tomo 札幌医科大学, 医学部, 大学院生
HIGUCHI Misako 市立小樽病院, 医師
KUMETA Yukihiro 札幌医科大学, 医学部, 臨床教授
SAITOU Katsuhiko 北海道薬科大学, 薬学部, 准教授
MORIYA Hiroyuki 北海道薬科大学, 薬学部, 助教
KUROSAWA Nahoko 北海道薬科大学, 薬学部, 教授
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | oprm1遺伝子 / ミューオピオイドレセプタ / 一塩基多型(SNPs) / 個人差 / 疼痛 / 遺伝子多型 / oprm1 / 麻薬 / ミューオピオイドレセブタ / oprml |
|---|
| Research Abstract |
We studied the individual differences in postoperative pain and opioid sensitivity. We focused on the single nucleotide polymorphisms (SNPs) of oprm1 gene. We showed the associations of opioid-induced emesis with haplotypes of eight SNPs of oprm1 gene. This new finding may contribute to prediction of the occurrence of nausea and vomiting in the preoperative period.
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