Grant-in-Aid for Young Scientists (B)
To clarify the cellular mechanisms of addiction with anesthetics, I performed extracellular field potential recording on rat VTA slices. I found that subclinical concentration of propofol (0.5μM) potentiated the field potential in VTA about 25 % of control value even though much higher concentration of propofol (5-50μM) suppressed it dose dependently. I could not evaluate influences of propofol in dopamine release in the VTA with in vitro setting.
Published : 2008-04-01
Modified : 2016-04-21
Attribution of KAKENHI