The effect of sevoflurane on simvastatin-induced eNOS expression in cultured endothelial cells.

• Project/Area Number: 20791090
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Wakayama Medical University
• Principal Investigator: TANGE Kazuaki 和歌山県立医科大学, 医学部, 助教 (70405471)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 麻酔学 / スタチン / 一酸化窒素 / 吸入麻酔薬 / 一酸化窒素合成酵素 / Rho Kinase / 酸化窒素合成酵素 / Rho kinase

Research Abstract

Acute exposure to simvastatin induces a rapid increase in endothelial NO producton and that sevoflurane inhibits the statin-induced increase in NO production. Exposure to simvastatin for 15 min induced an increase in eNOS expression in BAECs, and sevoflurane inhibited the increase in statin-induced eNOS expression.

Research Products

• [Presentation] The effect of sevoflurane on simvastatin-induced eNOS expression in cultured endothelial cells (2010)
  • Author(s): 丹下和晃
  • Organizer: 2010 annual meeting of American Society of Anesthesiologist
  • Year and Date: 2010-10-19
• [Presentation] The effect of sevoflurane on simvastatin-induced eNOS expression in cultured endothelial cells. (2010)
  • Author(s): 丹下和晃
  • Organizer: 2010 annual meeting of American Society of Anesthesiologist
  • Place of Presentation: サンディエゴ
  • Year and Date: 2010-10-19
• [Presentation] The effect of sevoflurane on simvastatin-induced eNOS expression in cultured endothelial cells. (2010)
  • Author(s): 丹下和晃
  • Organizer: 2010 annual meeting of American Society of Anesthesiologist
  • Place of Presentation: 米国カリフォルニア州 サンディエゴ
  • Year and Date: 2010-10-19
• [Presentation] evoflurane inhibits the increase in statin-induced endothelial nitric oxide synthase expression (2009)
  • Author(s): 丹下和晃
  • Organizer: 2009 annual meeting of American Society of Anesthesiologist
  • Year and Date: 2009-10-17
• [Presentation] Sevoflurane inhibits the increase in statin-induced endothelial nitri coxide synthase expression. (2009)
  • Author(s): 丹下和晃
  • Organizer: 2009 annual meeting of American Society of Anesthesiologist
  • Place of Presentation: ニューオリンズ
  • Year and Date: 2009-10-17
• [Presentation] Sevoflurane inhibits the increase in statin-induced endothelial nitricoxide synthase expression (2009)
  • Author(s): 丹下和晃
  • Organizer: 2009 annual meeting of American Society of Anesthesiologist
  • Place of Presentation: 米国ルイジアナ州ニューオリンズ
  • Year and Date: 2009-10-17
• [Presentation] Acute effect of simvastatin on Nitric Oxide synthesis in bovine aortic endothelial cells (2008)
  • Author(s): 丹下和晃
  • Organizer: 2008 annual meeting of American Society of Anesthesiologist
  • Year and Date: 2008-10-21