The effect of sevoflurane on simvastatin-induced eNOS expression in cultured endothelial cells.
| Project/Area Number |
20791090
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
TANGE Kazuaki 和歌山県立医科大学, 医学部, 助教 (70405471)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 麻酔学 / スタチン / 一酸化窒素 / 吸入麻酔薬 / 一酸化窒素合成酵素 / Rho Kinase / 酸化窒素合成酵素 / Rho kinase |
|---|
| Research Abstract |
Acute exposure to simvastatin induces a rapid increase in endothelial NO producton and that sevoflurane inhibits the statin-induced increase in NO production. Exposure to simvastatin for 15 min induced an increase in eNOS expression in BAECs, and sevoflurane inhibited the increase in statin-induced eNOS expression.
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Report
(6 results)
Research Products
(7 results)
