| Project/Area Number |
20791092
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Jichi Medical University |
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Principal Investigator |
SATO Yuki Jichi Medical University, 医学部, 助教 (50406047)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 痛み / シクロスポリン / perfusion index / 麻酔薬 / 中枢神経作用 / 痛み反応 |
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| Research Abstract |
In the setting of organ and stem-cell transplantation, calcineurin-inhibitor-induced pain syndrome (CIPS) has recently been recognized. In our study, we found that cyclosporine increases pain reaction, increases anxiety-related behavior, and disturbed social behavior by reducing the release of serotoin and dopamine in mice. In order to support these evidences in human, we have also examined the thermal noxious stimulation based on heat flux using the perfusion index and found that it could be a useful tool to evaluate pain reaction in clinical situation.
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