| Project/Area Number |
20791094
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Teikyo University |
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Principal Investigator |
SAKAMOTO Hidetoshi Teikyo University, 医学部, 講師 (90349267)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 脳・神経 / 薬理学 / 虚血再灌流 / 酸化ストレス / 虚血再潅流 / HMGB1 |
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| Research Abstract |
We demonstrated that 3-nitrotyrosine and 8-nitroguanosine, which are cytotoxic markers from the cerebral infarction cite, are not appropriate as markers of the cerebral ischemia-reperfusion injury. We also demonstrated that glycyrrhizin acid decreased an infarct size in a rat middle cerebral artery occlusion model, and that improved a neurological scoring. However, there was no correlation between neurological scoring and HMGB1 in cerebrospinal fluid, which was expected as a marker. HMGB1 in cerebrospinal fluid does not reflect the brain ischemia and damage, at least, in a rat middle cerebral artery occlusion model. Further investigation is required to confirm the possibility of HMGB1 as the marker of the cerebral ischemia-reperfusion injury.
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