Effects of endotoxemia on resistance arteriole : Effects on membrane potential on submucosal small intestine.

Research Project

Project/Area Number	20791098
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Nagoya City University
Principal Investigator	TAKANO Hiromichi Nagoya City University, 大学院・医学研究科, 助教 (70410313)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords	ショック / 敗血症 / 膜電位 / 細動脈 / LPS
Research Abstract	The effects of endotoxemia on the diameter change and the membrane potential of submucosal arteriole in guinea pig small intestine were simultaneously measured. The endotoxemia did not significantly change the membrane potential. Acetylcholine (Ach) repolarized and relaxed the vessel in presence of BaCl. Endotoximia inhibited these effects of ACh. The repolarization and vasorelaxation were due to the activation of the two types of the calcium dependent potassium channels. No difference on the role of these channels was observed between the control and the endotiximia model.

Report

(3 results)