Basic research for the anti cancer effect of Noscapine to Renal cell carcinoma and Prostate Cancer

• Project/Area Number: 20791103
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Kanazawa University
• Principal Investigator: MIYAGI Tohru Kanazawa University, 附属病院, 助教 (60467107)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: ノスカピン / 腎癌 / 前立腺癌 / 化学療法 / 腎細胞癌

Research Abstract

We confirmed the anticancer effect of Noscapine to Renal cell carcinoma cell line and Prostate cancer cell line, they had been thought to be resistant to previous reported chemotherapy. Although IC50 to these cell lines need rather high concentration, still Noscapine was thought to be of great value as one of candidate for chemotherapy to renal cell carcinoma and prostate cancer patients, because there are several reports of safety of high dose Noscapine to human being.