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Establishment of inflammation induced mouse prostate cancer

Research Project

Project/Area Number 20791106
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionOsaka University

Principal Investigator

NAKAI Yasutomo  Osaka University, 医学系研究科, 助教 (20432479)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords前立腺癌 / 炎症 / 食餌 / 前立腺炎 / PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) / PhIP
Research Abstract

Because no mouse had prostatitis after transurethral injection of lipopolysaccharide (LPS), we changed the animal from mouse to rat. Rats were treated with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) intragastrically. We analyzed the difference of the incidence rate of neoplastic lesions between rats treated with transurethral instillation of LPS and control rats. The incidence rate of atrophic lesions and dysplastic lesions, those are thought to be related to prostate carcinogenesis, was similar between LPS treated group and control group, however, the incidence rate of carcinoma in situ was statistically higher in LPS treated group. From these results, it is suggested that prostatitis might related to promotion rather than initiation of prostatic carcinogenesis.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (4 results)

All 2010 2009 Other

All Presentation (4 results)

  • [Presentation] 前立腺炎はPhIP(2-amino-1-methyl-6-phenylimidazo [4, 5-b]pyridine)による前立腺発癌を促進する2010

    • Author(s)
      中井康友、向井雅俊、鈴木崇、土屋睦美、房前裕順、波多野浩士、河嶋厚成、中山雅志、高山仁志、野々村祝夫、奥山明彦
    • Organizer
      第98回日本泌尿器科学会総会
    • Place of Presentation
      盛岡市民文化センター
    • Related Report
      2009 Final Research Report
  • [Presentation] 新規ラット前立腺炎モデルの確立-発癌研究への応用へ向けて-2009

    • Author(s)
      中井康友
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2009-04-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規ラット前立腺炎モデルの確立-発癌研究への応用に向けて-2009

    • Author(s)
      中井康友、河嶋厚成、向井雅俊、永原啓、芝政宏、中山雅志、高山仁志、西村和郎、野々村祝夫、奥山明彦
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山コンベンションセンター
    • Related Report
      2009 Final Research Report
  • [Presentation] Prostatitis promotes prostate carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo [4, 5-b]pyridine (PhIP)

    • Author(s)
      Yasutomo Nakai, Masatoshi Mukai, Takashi Suzuki, Mutsumi Tsuchiya, Yasuyuki Fusamae, Akira Nagahara, Masashi Nakayama, Hitoshi Takayama, Norio Nonomura
    • Organizer
      第69回日本癌学会総会(予定)
    • Related Report
      2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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