Establishment of inflammation induced mouse prostate cancer
| Project/Area Number |
20791106
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Osaka University |
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Principal Investigator |
NAKAI Yasutomo Osaka University, 医学系研究科, 助教 (20432479)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 前立腺癌 / 炎症 / 食餌 / 前立腺炎 / PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) / PhIP |
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| Research Abstract |
Because no mouse had prostatitis after transurethral injection of lipopolysaccharide (LPS), we changed the animal from mouse to rat. Rats were treated with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) intragastrically. We analyzed the difference of the incidence rate of neoplastic lesions between rats treated with transurethral instillation of LPS and control rats. The incidence rate of atrophic lesions and dysplastic lesions, those are thought to be related to prostate carcinogenesis, was similar between LPS treated group and control group, however, the incidence rate of carcinoma in situ was statistically higher in LPS treated group. From these results, it is suggested that prostatitis might related to promotion rather than initiation of prostatic carcinogenesis.
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Report
(3 results)
Research Products
(4 results)
