Enhancement of chemo-sensitivity by molecular-targeting drugs in gemcitabine-resistant advanced bladder cancer.

• Project/Area Number: 20791108
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Kobe University
• Principal Investigator: MURAMAKI Mototugu Kobe University, 医学部附属病院, 助教 (10448178)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 膀胱癌 / ジェムシタビン抵抗性 / 分子標的薬 / ジェムシタビン / 抗癌剤耐性 / 分子標的治療 / アポトーシス / in vivo study / Clusterin

Research Abstract

Clusterin plays significant role in the acquisition of chemo-resistant phenotype in bladder cancer cells and the inactication of Clusterin using OGX-011 combined with chemotherapeutic agent could be an attractive approach for advanced bladder cancer through the enhancement of chemo-sensitivity.

Research Products

• [Journal Article] Chemosensitization of gemcitabine-resistant human bladder cancer cell line both in vitro and in vivo using antisense oligonucleotide targeting the anti-apoptotic gene, clusterin. (2009)
  • Author(s): Muramaki M, So A, Hayashi N, Sowery R, Miyake H, Fujisawa M, Gleave ME.
  • Journal Title: BJU Int. 103(3) Pages: 384-390
• [Journal Article] Chemosensltization of gemeltablne-reslstant human bladder cancer cell line both in vitro and in vivo using antisense oligonucleotide targeting the anti-apoptotic gene, clusterin (2009)
  • Author(s): Muramaki M, So A, Hayashi N, Sowery R, Miyake H, Fujisawa M, Gleave ME
  • Journal Title: BJU Int 103 Pages: 384-390
  • Peer Reviewed
• [Presentation] Chemosensitization of gemcitabine-resistant human bladder cancer cell line both in vitro and in vivo using antisense oligonucleotide targetting the anti-apoptotic gene, clusterin. (2007)
  • Author(s): 村蒔基次
  • Organizer: 日本癌学会総会
  • Place of Presentation: clusterin