The significance of Aurora-A expression in prostate and renal cancer.

• Project/Area Number: 20791109
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Kobe University
• Principal Investigator: KUMANO Masafumi Kobe University, 医学部附属病院, 医学研究員 (30457105)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 前立腺癌 / 腎癌 / Aurora-A / 抗癌剤感受性 / siRNA / Aurora kinase

Research Abstract

The suppression of Aurora-A remarkably inhibited cell growth in prostate and renal cancer cells, and enhanced the sensitivity of anticancer agents.

Research Products

• [Journal Article] tumour growth and enhanced chemosensitivity by RNA interference targeting Aurora-A in the PC3 human prostate cancer model. (2009)
  • Author(s): Kumano M, Miyake H, Terakawa T, Furukawa J, Fujisawa M. Suppressed
  • Journal Title: BJU Int (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Suppressed tumour growth and enhanced chemosensitivity by RNA interference targeting Aurora-A in the PC3 human prostate cancer model (2009)
  • Author(s): 熊野晶文
  • Journal Title: BJU International Epub ahead of print
  • Peer Reviewed
• [Presentation] Suppressed progression and enhanced chemosensitivity of human renal cancer cells by siRNA targetting Aurora kinase A (2009)
  • Author(s): 寺川智章
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-10-02
• [Presentation] Groth inhibition and enhanced chemosensitivity both in vitro and in vivo by downregulation of Aurora-A in human prostate cancer PC3 cells using small interfering RNA. (2009)
  • Author(s): Masafumi Kumano, Hideaki Miyake, Atsushi Takenaka, Sadao Kamidono, Masato Fujisawa
  • Organizer: American Urological Association Annual Meeting
  • Place of Presentation: Chicago, USA
• [Presentation] Aurora kinase Aを標的としたSmall interfering RNAによるヒト前立腺癌細胞株PC3の進展抑制および抗癌剤感受性の亢進 (2008)
  • Author(s): 熊野晶文
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] Aurora kinase Aを標的としたSmall interfering RNAによるヒト前立腺癌細胞株PC3の進展抑制および抗癌剤感受性の亢進. (2008)
  • Author(s): 熊野晶文, 寺川智章, 古川順也, 村蒔基次, 倉橋俊史, 三宅秀明, 田中一志, 武中篤, 藤澤正人
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] ヒト前立腺癌細胞株PC3におけるSmall interfering RNA (siRNA)発現ベクターを用いたAurora-A発現抑制の意義. (2008)
  • Author(s): 熊野晶文, 寺川智章, 倉橋俊史, 村蒔基次, 曽我秀雄, 三宅秀明, 田中一志, 武中篤, 藤澤正人
  • Organizer: 第96回日本泌尿器科学会総会
  • Place of Presentation: 横浜