| Project/Area Number |
20791110
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
|
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| Research Institution | Okayama University |
|---|
Principal Investigator |
WADA Koichiro Okayama University, 岡山大学病院, 医員 (20423337)
|
|---|
| Research Collaborator |
KARIYAMA Reiko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40112148)
KUMON Hiromi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (30144760)
|
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 大腸菌 / バイオフィルム / 尿路感染症 / フルオロキノロン / 耐性メカニズム / 実験モデル系 / キノロン耐性 |
|---|
| Research Abstract |
This study was aimed at establishing new strategies for prevention and therapy of Escherichia coli biofilms in urinary tract infections. On the emergence of E. coli strains with increasing resistance to fluoroquinolones, the relationship between fluoroquinolone insusceptibility and biofilm-forming capabilities has not been clarified, but its multiple resistance mechanism was suggested. By a novel method to screen antibiofilm agents, some compounds from urine metabolites of cranberry were found, but further studies were needed to evaluate them in vivo models.
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