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Can doxycycline become new medicine in the last 50 years to reduce renal ischemia reperfusion injury?

Research Project

Project/Area Number 20791111
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionOkayama University

Principal Investigator

ARAKI Motoo  Okayama University, 岡山大学病院, 助教 (90467746)

Research Collaborator KAWAUCHI Keiichiro  岡山大学, 大学院・医歯薬学総合研究科, 大学院生
HIROHATA Satoshi  岡山大学, 大学院・医歯薬学総合研究科, 助教 (90332791)
NINOMIYA Yoshifumi  岡山大学, 大学院・医歯薬学総合研究科, 教授 (70126241)
Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords腎虚血再潅流障害 / ドキシサイクリン / 細胞外マトリックス(MMP) / MMP阻害薬 / 腎移植 / MMP
Research Abstract

We established murine renal ischemia reperfusion injury (IRI) model. Renal hilums of B6 mouse was clumped for 45 minutes under anesthesia. Body temperature was kept on 32℃. We have identified reduced IRI by measuring serum creatinine level and histopathology.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (8 results)

All 2010 2009

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results)

  • [Journal Article] Robot-assisted laparoscopic radical prostatectomy in the Asian population: Modified port configuration and ultradissection2010

    • Author(s)
      Wooju Jeong, 1Motoo Araki, et al
    • Journal Title

      International Journal of Urology 17

      Pages: 297-300

    • NAID

      10027257729

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] 腹腔鏡下尿膜管遺残摘出術の8例2010

    • Author(s)
      荒木元朗, ほか
    • Organizer
      日本内視鏡外科学会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-22
    • Related Report
      2009 Final Research Report
  • [Presentation] 術前6週間の免疫抑制で成功したハイリスク生体腎移植の1例2010

    • Author(s)
      荒木元朗, ほか
    • Organizer
      岡山腎疾患懇話会
    • Place of Presentation
      岡山
    • Year and Date
      2010-11-22
    • Related Report
      2009 Final Research Report
  • [Presentation] RETROGRADE URETEROPYELOSCOPIC TREATMENT OF LARGE UPPER URINARY TRACT AND STAGHORN CALCULI WITH AQUAGUIDE2010

    • Author(s)
      荒木元朗, ほか
    • Organizer
      World Congress of Endourology
    • Place of Presentation
      ミュンヘン、ドイツ
    • Year and Date
      2010-11-22
    • Related Report
      2009 Final Research Report
  • [Presentation] International Robotic Fellowship Program at Yonsei2010

    • Author(s)
      荒木元朗
    • Organizer
      Yonsei Urology Symposium (招請講演)
    • Place of Presentation
      ソウル、韓国
    • Year and Date
      2010-08-22
    • Related Report
      2009 Final Research Report
  • [Presentation] Ureteroscopic Evaluation and Treatment of Chronic Unilateral Hematuria: A 22-year Experience2010

    • Author(s)
      荒木元朗, ほか
    • Organizer
      American Urological Association Annual meeting
    • Place of Presentation
      シカゴ、アメリカ
    • Year and Date
      2010-04-22
    • Related Report
      2009 Final Research Report
  • [Presentation] 術前6週間の免疫抑制で成功したハイリスク生体腎移植の1例2010

    • Author(s)
      河内啓一郎
    • Organizer
      腎移植臨床学会
    • Place of Presentation
      高知
    • Year and Date
      2010-01-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 術前6週間の免疫抑制で成功したハイリスク生体腎移植の1例2009

    • Author(s)
      荒木元朗
    • Organizer
      透析懇詣会
    • Place of Presentation
      岡山
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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