| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
We employed male Sprague-Dawley rats with partial BOO as a LUTS model. Sham-operated animals were used as controls. Voiding and bladder functions of BOO rats were significantly worse than those of sham-operated animals at 4, 8 and 16 weeks after obstruction. Erectile function of BOO rats was significantly decreased compared to sham-operated animals at 16 weeks after obstruction, although it was similar to that of sham-operated animals at 4 and 8 weeks after obstruction. Endothelial nitric oxide synthase mRNA expression was significantly decreased at 16 weeks after obstruction compared to sham-operated animals. We established an animal model for study of the association of LUTS with ED. Endothelial dysfunction induced by impaired eNOS function may be involved in ED following LUTS/BOO.
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