The study of the relationship between lower urinary outlet symptoms/bladder outlet obstruction and erectile dysfunction
| Project/Area Number |
20791116
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
TOSHIAKI Tanaka Sapporo Medical University, 医学部, 研究員 (50398327)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 勃起障害 / 下部尿路通過障害 / 下部尿路症状 |
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| Research Abstract |
We employed male Sprague-Dawley rats with partial BOO as a LUTS model. Sham-operated animals were used as controls. Voiding and bladder functions of BOO rats were significantly worse than those of sham-operated animals at 4, 8 and 16 weeks after obstruction. Erectile function of BOO rats was significantly decreased compared to sham-operated animals at 16 weeks after obstruction, although it was similar to that of sham-operated animals at 4 and 8 weeks after obstruction. Endothelial nitric oxide synthase mRNA expression was significantly decreased at 16 weeks after obstruction compared to sham-operated animals. We established an animal model for study of the association of LUTS with ED. Endothelial dysfunction induced by impaired eNOS function may be involved in ED following LUTS/BOO.
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Report
(3 results)
Research Products
(5 results)
