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Analysis of miRNA expression and function in prostate cancer cells using bioinformatics

Research Project

Project/Area Number 20791117
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionYokohama City University

Principal Investigator

ISHIGURO Hitoshi  Yokohama City University, 医学研究科, 客員准教授 (00381666)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords前立腺癌 / miRNA
Research Abstract

Micro RNA (miRNA) is considered the responsibility of growth and invasion in some cancer cells. However, the function of miRNA is still unclear. We investigated miRNA expression and the function in prostate cancer. We used the databases of miRNA and the genome abnormality sites in prostate cancer for the screening of the target miRNA. Further, we examined the expression of miRNA in prostate cancer tissues and prostate cancer cell lines using quantitative PCR. As the result, we found miR-30d. The inhibitor for miR-30d was reduced the growth of prostate cancer cell lines. Thus, these data was suggested that miR-30d had an important role for prostate cancer cell growth.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (6 results)

All 2010 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results)

  • [Journal Article] Analysis of NSAIP-activted gene 1 expression in prostate cancer.2010

    • Author(s)
      Kawahara T, Ishiguro H, Hoshino K, et al.
    • Journal Title

      Urologia Internationalis. 84(2)

      Pages: 198-202

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] aPKCl/i promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6.2009

    • Author(s)
      Ishiguro H, Akimoto K, Nagashima Y, Kojima Y, Sasaki T, Ishiguro-Imagawa Y, Nakaigawa N, Ohno S, Kubota Y, Uemura H
    • Journal Title

      Proc Natl Acad Sci U S A 106

      Pages: 16369-16374

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] aPKCl/i promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6.2009

    • Author(s)
      Ishiguro H, Akimoto K, Nagashima Y, et al.
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America. 106(38)

      Pages: 16369-16374

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 前立腺癌におけるApkcの発現と前立腺癌進展機構2009

    • Author(s)
      石黒斉, 秋本和憲, 長嶋洋治, 他
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2009-04-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 前立腺癌におけるaPKCの発現と前立腺癌進展機構2009

    • Author(s)
      石黒斉, 秋本和憲, 長嶋洋治, 小島康幸, 佐々木毅, 上村博司, 大野茂男, 窪田吉信
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山
    • Related Report
      2009 Final Research Report
  • [Presentation] The role of aPKC lambda in prostate cancer progression.2008

    • Author(s)
      石黒斉, 秋本和憲, 長嶋洋治, 小島康幸, 石黒由香利, 佐々木毅, 上村博司, 大野茂男, 窪田吉信
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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