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The contribution of cyclin dependent kinase inhibitor p57 to prostate cancer hormone resistance

Research Project

Project/Area Number 20791118
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionNagoya City University

Principal Investigator

NAGATA Daisuke  Nagoya City University, 大学院・医学研究科, 研究員 (20336689)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords前立腺癌 / 細胞周期 / サイクリン依存性キナーゼヒビター / p57 / サイクリン依存性キナーゼインヒビター / PPARγ / サイクリン依存性キナーラセインヒビター
Research Abstract

The androgen receptor occurs the prostate cancer in the androgen dependence by the nuclear receptor that belongs to the steroid receptor, and takes part in proliferation. It has decreased in the androgen dependency prostate cancer cell though cyclin E and cyclin D1 that was the positive cell cycle restrictor admitted the high expression by the androgen non-dependency prostate cancer cell. On the other hand, the appearance of cyclin dependent kinase inhibitor p57 that is a negative restrictor has decreased obviously by the androgen non-dependency prostate cancer cell. Also as for the prostate tissue immunity dye, the appearance of p57 decreased in the prostate cancer leision compared with the prostate normal leision, and the appearance of p57 was hardly admitted in the prostate cancer leision that had become a hormone resistance.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (7 results)

All 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results)

  • [Journal Article] Peroxisome proliferator-activated receptor-γ and growth inhibition by its ligands in prostate cancer.2008

    • Author(s)
      Nagata Daisuke, Hashimoto Yoshihiro, Nakanishi Makoto, Naruyama Hiromichi, Okada Shinsuke, Ando Ryosuke, Tozawa Keiichi, Kohri Kenjiro
    • Journal Title

      Cancer Detection and Prevention 32

      Pages: 259-266

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peroxisome proliferator-activated receptor-gamma and growth inhibition by its ligands in prostate cancer2008

    • Author(s)
      Nagata D, Hashimoto Y, et.al.
    • Journal Title

      Cancer Detect Prev. 32

      Pages: 259-66

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 限局性前立腺癌に対する治療選択-腹腔鏡下前立腺全摘除術vs強度変調放射線治療(IMRT)-2009

    • Author(s)
      戸澤啓一、橋本良博、梅本幸裕、永田大介、秋田英俊、伊藤恭典、安井孝周、芝本雄太、郡健二郎
    • Organizer
      第23回日本Endourology ・ESWL学会総会
    • Place of Presentation
      東京都
    • Related Report
      2010 Final Research Report
  • [Presentation] 腹腔鏡下前立腺全摘除術後の再発予測因子の検討2009

    • Author(s)
      戸澤啓一、梅本幸裕、橋本良博、郡健二郎、河合憲康、永田大介、秋田英俊、安井孝周、伊藤恭典
    • Organizer
      第59回日本泌尿器科学会中部総会
    • Place of Presentation
      金沢市
    • Related Report
      2010 Final Research Report
  • [Presentation] 限局性前立腺癌の治療選択-腹腔鏡下前立腺全摘除術vs IMRT-2009

    • Author(s)
      戸澤啓一、橋本良博、河合憲康、永田大介、秋田英俊、岡村武彦、安藤亮介、芝本雄太、郡健二郎
    • Organizer
      第47回日本癌治療学会学術集会
    • Place of Presentation
      横浜市
    • Related Report
      2010 Final Research Report
  • [Presentation] 限局性前立腺癌に対する治療成績-腹腔鏡下前立腺全摘除術vs強度変調放射線治療(IMRT)2009

    • Author(s)
      戸澤啓一、橋本良博、梅本幸裕、永田大介、秋田英俊、伊藤恭典、安井孝周、馬場二三八、芝本雄太、郡健二郎
    • Organizer
      第21回日本内分泌外科学会総会
    • Place of Presentation
      岡山市
    • Related Report
      2010 Final Research Report
  • [Presentation] 限局性前立腺癌に対する治療成績-腹腔鏡下前立腺全摘術vs強度変調放射線治療(IMRT)2009

    • Author(s)
      戸澤啓一、橋本良博、安藤亮介、池上要介、永田大介、秋田英俊、林祐太郎、馬場二三八、芝本雄太、郡健二郎
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山市
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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