| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
By establishing tetracycline-inducible overexpression in ES cells, our data suggest that Pax2 and additional factors that are induced in the embryoid bodies synergistically upregulate the integrin α 8 and AQP1 that are possibly involved in kidney development. Our method for the generation of tetracycline-inducible ES cell lines will be useful for dissecting the genetic cascades functioning in the early stages of development, as well as for screening candidate genes that direct ES cells toward the desired lineages, which may be applicable to future cell therapies.
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