Study for biological function in prostate cancer of SND1 and its role for therapeutic target.

• Project/Area Number: 20791124
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Jikei University School of Medicine
• Principal Investigator: KIMURA Takahiro Jikei University School of Medicine, 医学部, 助教 (00307430)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 癌 / 泌尿器科 / 前立腺癌 / バイオマーカー

Research Abstract

The aim of the study was to elucidate the biological function of SND1 in prostate cancer. Transgenic mouse expressed SND1 prostate-specifically was produced and the prostate was observed histologically. At the 18 months old, cancer was not observed in the prostate. To observe the molecular change according to SND1 expression, microarray was performed using total RNA extracted from the prostate. Change of expression was compared between TG and control mice and the change was confirmed by real time PCR. Some molecules were identified and thought to have roles in carcinogenesis of prostate cancer.