Investigation of prostate cancer stem cells

Research Project

Project/Area Number	20791126
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Urology
Research Institution	Jikei University School of Medicine
Principal Investigator	MIKI Jun Jikei University School of Medicine, 医学部, 助教 (00328361)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	前立腺癌 / 癌幹細胞
Research Abstract	Recent evidence supports the cancer stem cell theory, that is, that tumors arise from cells termed cancer stem cells (CSC) or tumor-initiating cells that have the ability of self-renewal and are responsible for maintaining the tumor. We established primary culture cell lines with Lentivirus vector from the specimen of prostatectomy. We analyzed the characterization of cells from JDCaP which is a novel PCa xenograft moldel. These cells consisted of heterogeneous population, and they may contain the stemness as CSC.These novel in vitro and in vivo models may offer useful tools for the study of the biological features and functional integration of normal and cancer stem cells in prostate.