Fundamental researches for clinical application of the fetal gene therapy using an adeno-associated virus vector

Research Project

Project/Area Number	20791131
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Obstetrics and gynecology
Research Institution	University of Tsukuba
Principal Investigator	OGURA Tsuyoshi University of Tsukuba, 大学院・人間総合科学研究科, 講師 (40451702)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	アデノ随伴ウイルス(AAV)ベクター / 血清型 / 胎児遺伝子治療 / AAV / 妊婦 / 抗体保有率
Research Abstract	"Gene therapy" treats disease at a genetic level.An AAV vector attracts attention from a safe aspect, and there are various models (serotype).I investigated serotype of the AAV vector which was suitable for fetal gene therapy.It became clear that an AAV1 type vector was suitable.Clinical application of fetal gene therapy was expected by developing these results.