| Project/Area Number |
20791133
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
KAKU Hiroshi Chiba University, 大学院・医学研究部, 協力研究員 (40456059)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 胞状奇胎 / 侵入奇胎 / 雄核発生奇胎 / SNPsアレイ / 遺伝子増幅 / LOH / コピー数変化 / コピーナンバー多型 / 続発症 / マイクロアレイ / 雄核発生 / 雄核 |
|---|
| Research Abstract |
Hydatidiform mole (HM) occurs in about 1 in 400 pregnancies in Japan. There are two different HM entities: androgenetic diploid 'complete' hydatidiform mole (CHM) and triploid 'partial' hydatidiform mole (PHM). CHM has a higher risk of GTN than PHM. It has been estimated that 10-30% of CHM develops GTN. However, we cannot predict which cases develop to gestational trophoblastic neoplasia. We applied 8 cases complete moles (CHM) to high density SNPs array of Affymetrix, and analyzed the array data with Affymetrix Genotyping Console and Microsoft Excel. 1) Homozygous CHM assessed with STR polymorphism analysis were confirmed the homozygosity in whole genome level. 2) We found specific regions in CHM. 3) We found two GTN specific region in chromosome 2 and 22.
|
