Screening of epigenetic regulatory gene in carcinogenesis of cervical adenocarcinoma

• Project/Area Number: 20791136
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Chiba University
• Principal Investigator: KANETANI Hiromi Chiba University, 医学部附属病院, 医員 (70456060)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 子宮頚癌 / エピジェネティック / メチル化 / 子宮頸癌

Research Abstract

The epigenetic gene alteration is suggest to involved in carciogenesis of cervical cancer. We confirmed high methylation of HIC -I, RASFFIA, and APC for cervical adenocarcinoma By the results of the microarray, we were not able to identify the candidate of the cancer suppressor gene which caught the epigenetic regulation.

Research Products

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