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Activation of hypoxia-inducible factor 1 by Human Papillomavirus Oncoproteins

Research Project

Project/Area Number 20791138
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionKanazawa University

Principal Investigator

NAKAMURA Mitsuhiro  Kanazawa University, 附属病院, 医員 (50377397)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsHPV / 低酸素 / 子宮頸癌 / HIF-1 / 子宮頚癌
Research Abstract

Our studies indicate that cells containing complete HPV31 genomes showed enhanced levels of HIF-1α upon treatment with the hypoxia mimic DFO, which resulted from protein stabilization and led to increased expression of VEGF. Both HPV E6 and E7 were able independently to enhance induction of HIF-1α upon DFO treatment. Our studies further indicate that HPV31 E7 associates with both HIF-1α and p53 in cells, and this association results in reduced interaction of the HIF-1α/p53 complex with MDM2. These findings shed light on mechanisms by which HPV contributes to angiogenesis both in benign cervical lesions and in cervical cancers and describes a novel role of the E7 oncogene in the virus-host interaction.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (8 results)

All 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results)

  • [Journal Article] Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses.2009

    • Author(s)
      Mitsuhiro Nakamura, Jason M. Bodily, Melanie Beglin, Satoru Kyo, Masaki Inoue, Laimonis A. Laimins
    • Journal Title

      Virology 387(2)

      Pages: 442-448

    • NAID

      120001256668

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia-specific stabilization of HIF-lalpha by human papillomavirus2009

    • Author(s)
      中村充宏
    • Journal Title

      Virology 387

      Pages: 442-448

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia-specific stabilization of HIF?lalpha by human papillomavirus2009

    • Author(s)
      中村充宏
    • Journal Title

      Virology (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Hypoxia-inducible factor, HIF-1α, is Induced by Human Papillomavirus Oncoproteins2009

    • Author(s)
      中村充宏
    • Organizer
      25th International Papillomavirus conference
    • Place of Presentation
      Malmo Exhibition & Convention center、マルメ, (スエーデン)
    • Year and Date
      2009-05-12
    • Related Report
      2009 Final Research Report
  • [Presentation] Hypoxia-inducible factor, HIF-1α, is Induced by Human Papillomavirus Oncoproteins2009

    • Author(s)
      中村充宏
    • Organizer
      25^<th> International Papillomavirus conference
    • Place of Presentation
      Malmo Exhibition & Convention center、マルメ、(スエーデン)
    • Year and Date
      2009-05-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 子宮頚癌におけるHPV癌遺伝子によるHIF-1活性化の分子機構2009

    • Author(s)
      中村充宏
    • Organizer
      第61回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2009-04-05
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] HPVがん遺伝子E6、E7によるHIF-1a発現上昇とその意義2008

    • Author(s)
      中村充宏
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2008-10-29
    • Related Report
      2009 Final Research Report
  • [Presentation] HPVがん遺伝子E6、E7によるHIF-1a発現上昇とその意義2008

    • Author(s)
      中村充宏
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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