Allelic expression difference of endometrial cancer

Research Project

Project/Area Number	20791148
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Obstetrics and gynecology
Research Institution	Kyushu University
Principal Investigator	SHUICHI Taniguchi Kyushu University, 医学研究院, 助教 (70452711)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	ゲノム / 子宮体癌 / 対立遺伝子間発現量
Research Abstract	In the hormone dependent cancers such as endometrial cancers and breast cancers, it aimed to clarify how the genomic diversification of the gene that composed p14ARF/MDM2/p53/p21 signalosome took part in the development of carcinoma. We analyzed each sample of the controls and the endometrial cancer patients. We analyzed the gene polymorphisms that existed in MDM2 SNP309T/G, p53 codon72 Arg/Pro, ER α Pvu2 T/C・Xba1 A/G, and p21 codon31 Ser/Arg. The odds ratio to the MDM2 SNP309 T/T type to G/G type in cancer patients did not admit a significant difference in statistics. The combination of MDM2 SNP309 and p53 codon72 showed the rise of the endometrial cancer odds ratio.