The role of genetic polymorphisms in polycystic ovary syndrome

• Project/Area Number: 20791154
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Sapporo Medical University
• Principal Investigator: BABA Tsuyoshi Sapporo Medical University, 医学部, 講師 (60404654)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 多嚢胞性卵巣症候群 / 遺伝子多型 / インスリン抵抗性 / アディポサイトカイン / アンドロゲン

Research Abstract

We revealed that the SNPs IRS-1 Gly972Arg and RETN-420 C/G are predisposing factors in PCOS. PCOS patients who have RETN-420 homozygous variant genotype showed significantly higher BMI, higher fasting serum insulin levels, and lower serum adiponectin levels.

Research Products

• [Journal Article] The contributions of resistin andadiponectin gene single nucleotide polymorphisms to the genetic risk for polycystic ovary syndrome in a Japanese population. (2009)
  • Author(s): Baba T, Endo T, Sata F, Nagasawa K, Honnma H, Kitajima Y, Hayashi T, Manase K, Kanaya M, Moriwaka O, Kamiya H, Yamada H, Minakami H, Kishi R, Saito T.
  • Journal Title: Gynecol Endocrinol. 25 Pages: 498-503
  • Peer Reviewed
• [Journal Article] The contributions of resitin and adiponectin gene single nucleotied polymorphisms to the gemetoc risk for polycystic ovary syndrome in a Japanese population (2009)
  • Author(s): BABA T, et al.
  • Journal Title: Gynecological Endocrinology 25 Pages: 498-503
  • Peer Reviewed
• [Presentation] 多嚢胞性卵巣症候群の遺伝的素因(ワークショップ「PCOSをめぐる卵胞発育機構の基礎研究」) (2010)
  • Author(s): 馬場剛
  • Organizer: 第28回日本受精着床学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-07-28
• [Presentation] 多嚢胞性卵巣症候群の遺伝的素因(ワークショップ「PCOSをめぐる卵胞発育機構の基礎研究」) (2010)
  • Author(s): 馬場剛
  • Organizer: 日本受精着床学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-07-28