Clarification of sperm protein phosphory I at i on/dephosphory I at i on mechanism in sperm capacitation

• Project/Area Number: 20791159
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Jichi Medical University
• Principal Investigator: SUZUKI Tatsuya Jichi Medical University, 医学部, 講師 (90348003)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: タンパク質 / プロテオーム / シグナル伝達 / 生理学 / 発生・分化 / 精子 / 超活性化 / リン酸化 / プロテインフォスファターゼ

Research Abstract

It has been widely accepted that phosphoprotein phosphatases (PPPs) are associated with the regulation of sperm hyperactivation. In the present study, we examined the types of PPPs associated with the regulation of hamster sperm hyperactivaton. From the results, it is likely that PPP2 is closely associated with the regulation of sperm hyperactivation, although it is not associated with the regulation of tyrosine phosphorylation.

Research Products

• [Journal Article] Regulation of hyperactivation by PPP2 in hamster spermatozoa. (2010)
  • Author(s): Suzuki T, Fujinoki M, Shibahara H, Suzuki M
  • Journal Title: Reproduction 139 Pages: 847-856
  • Peer Reviewed
• [Journal Article] 精子のcapacitation. (2010)
  • Author(s): 鈴木達也、柴原浩章、鈴木光明
  • Journal Title: 日本哺乳動物卵子学会誌 27 Pages: 166-175
  • NAID: 10027595255
  • Peer Reviewed
• [Journal Article] Regulation of hyperactivation by PPP2 in hamster spermatozoa. (2010)
  • Author(s): 鈴木達也、藤ノ木政勝、柴原浩章、鈴木光明
  • Journal Title: Reproduction Volume: 139 Pages: 847-856
  • Peer Reviewed
• [Journal Article] 精子のcapacitation (2010)
  • Author(s): 鈴木達也、柴原浩章、鈴木光明
  • Journal Title: 日本哺乳動物卵子学会誌 Volume: 27 Pages: 166-175
  • NAID: 10027595255
  • Peer Reviewed
• [Journal Article] Regulation of hyperactivation by PP2A on hamster spermatozoa
  • Author(s): 鈴木達也、藤ノ木政勝、柴原浩章、鈴木光明
  • Journal Title: Reproduction (印刷中)
  • Peer Reviewed
• [Presentation] ハムスター精子においてPPP2は超活性化の調節に関与する (2010)
  • Author(s): 鈴木達也、藤ノ木政勝、柴原浩章、鈴木光明
  • Organizer: 第55回日本生殖医学会
  • Place of Presentation: ホテルクレメント徳島
  • Year and Date: 2010-11-12
• [Presentation] 精子超活性化に関与するプロテインフォスファターゼサブファミリーは2Aである (2010)
  • Author(s): 鈴木達也、柴原浩章、鈴木光明
  • Organizer: 第62回日本産科婦人科学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-04-23
• [Presentation] プロテインフォスファターゼ(PP)2Aは精子超活性化に関与する (2008)
  • Author(s): 鈴木達也
  • Organizer: 第26回日本受精着床学会総会・学術講演会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2008-08-28
• [Remarks] ホームページ等
  • URL: http://rseeds.jichi.ac.jp/research_seeds/public/ResearchResultDetail.php?publicId=9GluMgt7Yu649vlJgCXbgWz44HDJ1f&resu1tCd=1&sectionCd=236