| Project/Area Number |
20791161
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kitasato University |
|---|
Principal Investigator |
KUZUOKA Mizuho Kitasato University, 医学部, 助教 (10365158)
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|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
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| Keywords | 子宮頚癌 / 子宮頚管炎 / HPV遺伝子型 / 炎症関連因子 / ゲノム不安定性 / HPV感染 / 慢性炎症 / 免疫染色 / 子宮頚部病変 |
|---|
| Research Abstract |
HPV types 16, 52, 58 and 31 were frequently detected in Japanese women with cervical neoplasias and several unspecified-risk HPV might be high-risk types. A single infection of high risk type HPV,punctate signal pattern,inflammation markers(NF-kβand iNOS), genomic instability (LOH and MSI) seemed to be closely correlated with cervical carcinogenesis.
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