Analysis of immune escape mechanism in cervical cancer that aims at immunotherapeutic application
Project/Area Number |
20791163
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Obstetrics and gynecology
|
Research Institution | Keio University |
Principal Investigator |
NISHIO Hiroshi Keio University, 医学部, 助教 (90445239)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 子宮頸癌 / 腫瘍免疫学 / 免疫逃避 / B7ファミリー / 免疫抑制 / シグナル伝達系 / MAPK / HPV |
Research Abstract |
Immune suppressive molecules including PD-L1 and B7-DC was evaluated in cervical cancer cell lines by ELISA or FACS method. Activation of intracellular signaling pathways was detected by western blotting method. As a result, PD-L1 and B7-DC protein in SKGII cells was depend on Erk1/2 cascade specifically and not associated with HPV E6/E7 protein.
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Report
(3 results)
Research Products
(1 results)