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Generating Synthetic Anti-HPV18 E7 Peptide

Research Project

Project/Area Number 20791167
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionKeio University

Principal Investigator

ONO Akiko  Keio University, 医学部, 研究員(非常勤) (70383883)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords癌 / ウイルス / タンパク質 / 蛋白質
Research Abstract

Quantitative binding assay system to investigate the interaction between HPV18 E7 and RB was constructed as expression plasmids. Peptide construct including LxCxE motif showed a certain but labile amount of inhibitory effect .Adjustment of the peptide by adding a pentamerization domain showed stronger inhibitory effect. Cell viability assay did not show significant difference due to poor plasmid transfection efficiency. Adenovirus vectors expressing the pentamerized peptides were constructed for improvement.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (3 results)

All 2008

All Presentation (3 results)

  • [Presentation] BAC Microarray-CGH法を用いた子宮頸癌のゲノム変化解析2008

    • Author(s)
      大野暁子
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-11
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Detections of Genomic Alterations in Uterine Cervical Cancer Using BAC Microarray2008

    • Author(s)
      大野暁子
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-28
    • Related Report
      2009 Final Research Report
  • [Presentation] Detections of Genomic Alterations in Uterine Cervical Cancer Using BAC Microarray2008

    • Author(s)
      大野暁子
    • Organizer
      第67回癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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